. Author manuscript; available in PMC: 2011 Jul 2.

Published in final edited form as: Nat Genet. 2009 Jan 25;41(2):211–215. doi: 10.1038/ng.313

Table 1.

Association of LCE3C_LCE3B-del with Psoriasis in 2,832 Caucasian Subjects from Different Populations

Population (samples)	Phenotype	Alleles	LCE3C_LCE3B-del (%)	LCE3C_LCE3B (%)	OR 95%CI	P-value
Spanish (557)	Psoriasis	350	225 (64)	125 (36)	1.47 (1.28–1.72)	0.0028
Spanish (557)	Control	764	420 (55)	344 (45)

Italian replicate (900)	Psoriasis	900	573 (64)	327 (36)	1.30 (1.12–1.51)	0.006
Italian replicate (900)	Control	900	516 (57)	384 (43)

Dutch replicate (484)	Psoriasis	408	281 (69)	127 (31)	1.50 (1.29–1.74)	0.0033
Dutch replicate (484)	Control	560	334 (60)	226 (40)

USA replicate (890)	Psoriasis	1,192	847 (71)	345 (29)	1.36 (1.18–1.58)	0.0038
USA replicate (890)	Control	588	378 (64)	210 (36)

Total (2,831)	Psoriasis	2,852	1,926 (68)	924 (32)	1.38 (1.19–1.61)	1.38E-08
Total (2,831)	Control	2,812	1,648(59)	1,164(41)

Odds ratio (OR) and 95% confidence interval 95% (CI) for LCE3C_LCE3B deleted allele (LCE3C_LCE3B-del) and psoriasis were obtained by logistic regression, overall and separately for each of the four populations; Overall OR and p-values are standardized by population according to a logistic model in which population was introduced as a confounding variable after (non-significant) heterogeneity was detected by population.