Table 2.
Association of rs4112788 Genotypes in the LCE Cluster with Psoriasis in Spanish, Italian, Dutch and USA Samples
| Recessive model C/C versus T/T and C/T |
Dominant model C/C and C/T versus T/T |
Log-additive model |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Population | Psoriasis* | Controls* | OR | 95%CI | OR | 95%CI | OR | 95%CI | P-value | r2 |
| By study | ||||||||||
| Spanish | 175 | 382 | 1.58 | 1.09–2.30 | 2.67 | 1.46–4.88 | 1.62 | 1.23–2.13 | 4.93E-04 | 0.92 |
| Italian | 449 | 446 | 1.35 | 1.03–1.77 | 1.54 | 1.06–2.24 | 1.30 | 1.08–1.58 | 0.0065 | 0.88 |
| Dutch | 202 | 278 | 1.50 | 1.04–2.17 | 2.08 | 1.17–3.70 | 1.47 | 1.12–1.93 | 0.0046 | 0.99 |
| USA | 587 | 293 | 1.46 | 1.10–1.94 | 1.54 | 0.93–2.55 | 1.38 | 1.10–1.72 | 0.0051 | 0.95 |
|
| ||||||||||
| Overall | 1,413 | 1,399 | 1.54 | 1.32–1.79 | 1.98 | 1.57–2.49 | 1.48 | 1.33–1.66 | 3.38E-12 | |
| Overall adjusted | 1,413 | 1,399 | 1.45 | 1.24–1.70 | 1.79 | 1.41–2.28 | 1.41 | 1.25–1.58 | 6.56E-09 | |
Odds ratio (OR) and 95% confidence interval (CI) for psoriasis comparing homozygous (C/C), heterozygous (C/T) and homozygous genotype (T/T) of rs411178 overall and separately for each of the four populations; Overall OR are standardized by population according to a logistic model in which population was introduced as a confounding variable after (non-significant) heterogeneity was detected by population; P-values are derived from the log-additive model, with homozygotes for the C allele at higher risk for psoriasis than homozygotes for TT as a basal genotype; Predictive performance of LCE3C_LCE3B deleted allele is presented for each population using the coefficient of determination measure (r2);
Subjects with valid call for rs4112788.