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. 2010 Jun 24;20(2):289–300. doi: 10.1089/scd.2009.0444

Table 1.

Genes of Interest Upregulated in Cocultures

  Symbol ID Expression ratio
Rat neural stem cell genes
 Differentiation
  Glial fibrillary acidic protein Gfap 24387 44.8a
  Bone morphogenetic protein 4 Bmp4 25296 2.7
  Meteorin Metrn 287151 2.2
 Notch signaling
  Delta-like 1 Dll1 84010 2.5b
 Intracellular signaling/transcription factors
  Lymphoid enhancer binding factor 1 Lef1 161452 4.1
  Tribbles homolog 1 Trib1 78969 4.0b
  Protein tyrosine phosphatase N Ptprn 116660 3.4
  Protein tyrosine phosphatase 5 Ptpn5 29644 2.7b
  Protein kinase C eta Prkch 81749 2.5
  Early growth response 1 Egr1 24330 2.3
  Signan transducer and activator of transcription 3 Stat3 25125 2.1
 Myelin related proteins
  Discoidin domain receptor family 1 Ddr1 25678 2.3
  Plasma membrane proteolipid Pllp 64364 2.2
  Gelsolin Gsn 296654 2.2
 Regulators in development
  Reelin Reln 24718 7.5
  Netrin 1 Ntn1 114523 2.6
  Chondroitin sulfate proteoglycan 2 Cspg2 114122 2.1
Human mesenchymal stromal cell genes
 Notch signaling
  Hairy and enhancer of split 1 HES1 3280 5.4
  Notch homolog 3 NOTCH3 4854 5.0
  Jagged 1 JAG1 182 4.2
  SMAD family member 3 SMAD3 4088 2.7
 Secreted factors
  Bone morphogenetic protein 1 BMP1 649 3.3
  Hepatocyte growth factor HGF 3082 3.2
  Transforming growth factor beta 3 TGFB3 7043 3
  Transforming growth factor beta 1 TGFB1 7040 2.4
 Cell surface receptors
  Thy-1 cell surface antigen THY1 7070 2.3
  KIT ligand KITLG 4254 2.3
  Glypican 1 GPC1 2817 2.3
a

Using a 90% confidence interval, change in transcript expression was not found to be significant due to high variance between individual perfect match and mismatch probes. Signal absent in NSCs alone.

b

Signal absent in NSCs alone.

NSC, neural stem cell.