Table 2.

Biodistribution of the four PET tracers and ratio of activity in CycA versus control male SD rats

[11C]6 %ID/gram	5 min No Rx	30 min No Rx		30 min CycA		CycA:No Rxa
Blood	0.057 ± 0.011	0.025	± 0.002	0.029	± 0.004	1.16
Lung	1.964 ± 0.341	0.688	± 0.076	0.647	± 0.053	0.94
Liver	1.525 ± 0.331	2.098	± 0.220	2.021	± 0.170	0.96
Kidney	2.691 ± 0.330	1.959	± 0.151	1.902	± 0.111	0.97
Muscle	0.062 ± 0.012	0.071	± 0.012	0.085	± 0.013	1.18
Fat	0.024 ± 0.009	0.064	± 0.010	0.037	± 0.003	0.58b
Total brain	0.189 ± 0.014	0.107	± 0.011	0.942	± 0.141	8.82c

[18F]7 %ID/gram	5 min No Rx	5 min CycA	30 min No Rx	30 min CycA	CycA:No Rxa
Blood	0.133 ± 0.018	0.156 ± 0.033	0.167 ± 0.018	0.178 ± 0.018	1.06
Lung	1.182 ± 0.086	1.423 ± 0.262	0.668 ± 0.057	0.563 ± 0.016	0.84d
Liver	2.035 ± 0.578	1.790 ± 0.286	2.169 ± 0.113	1.870 ± 0.184	0.86e
Kidney	1.582 ± 0.293	1.782 ± 0.242	0.952 ± 0.100	0.898 ± 0.076	0.94
Muscle	0.107 ± 0.017	0.158 ± 0.055	0.143 ± 0.011	0.147 ± 0.006	1.03
Fat	0.084 ± 0.036	0.062 ± 0.017	0.086 ± 0.013	0.069 ± 0.011	0.81
Bone	0.243 ± 0.041	0.232 ± 0.015	0.164 ± 0.018	0.168 ± 0.016	1.02
Total brain	0.067 ± 0.011	0.421 ± 0.115	0.098 ± 0.012	0.271 ± 0.068	2.77f

[18F]8 %ID/gram	5 min No Rx	5 min CycA	30 min No Rx	30 min CycA	CycA:No Rxa
Blood	0.079 ± 0.006	0.109 ± 0.009	0.046 ± 0.008	0.062 ± 0.018	1.35
Lung	2.432 ± 0.211	1.893 ± 0.158	1.553 ± 0.179	1.154 ± 0.102	0.74
Liver	2.124 ± 0.113	1.770 ± 0.584	2.134 ± 0.313	2.431 ± 0.365	1.14
Kidney	2.939 ± 0.544	2.235 ± 0.175	2.710 ± 0.235	2.548 ± 0.490	0.94
Muscle	0.099 ± 0.007	0.184 ± 0.014	0.111 ± 0.006	0.154 ± 0.038	1.38
Fat	0.101 ± 0.046	0.116 ± 0.004	0.095 ± 0.017	0.115 ± 0.030	1.20
Bone	0.490 ± 0.033	0.288 ± 0.008	0.882 ± 0.153	0.599 ± 0.152	0.68
Total brain	0.178 ± 0.030	0.895 ± 0.063	0.180 ± 0.006	0.970 ± 0.077	5.38g

[18F]9 %ID/gram	5 min No Rx	5 min CycA	30 min No Rx	30 min CycA	CycA:No Rxa
Blood	0.082 ± 0.027	0.098 ± 0.009	0.104 ± 0.010	0.109 ± 0.019	1.05
Lung	4.026 ± 1.177	3.356 ± 0.261	1.313 ± 0.3574	1.063 ± 0.182	0.81
Liver	1.430 ± 0.221	1.478 ± 0.336	1.162 ± 0.1400	1.039 ± 0.124	0.89
Kidney	2.485 ± 0.608	1.913 ± 0.037	1.363 ± 0.0359	1.397 ± 0.260	1.03
Muscle	0.083 ± 0.009	0.097 ± 0.0417	0.083 ± 0.0139	0.108 ± 0.014	1.24
Fat	0.028 ± 0.003	0.046 ± 0.028	0.091 ± 0.0029	0.093 ± 0.017	1.02
Bone	0.253 ± 0.001	0.162 ± 0.030 g	0.220 ± 0.0494	0.143 ± 0.016	0.65
Total brain	0.118 ± 0.001	0.725 ± 0.022	0.095 ± 0.0208	0.504 ± 0.023	5.33h

^aRatio of tracer uptake in CycA versus control group 30 min post injection

^bP value = 0.00682

^cP value = 0.00007

^dP value = 0.01232

^eP value = 0.03230

^fP value = 0.00246

^gP value < 0.00001

^hP value < 0.00001