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. Author manuscript; available in PMC: 2011 Jul 2.
Published in final edited form as: Alcohol Clin Exp Res. 2008 Jul 24;32(10):1774–1781. doi: 10.1111/j.1530-0277.2008.00762.x

Fig. 3. Effect of pretreatment with the aldehyde dehydrogenase inhibitor cyanamide on ethanol-induced 3α,5α-THP elevation.

Fig. 3

Animals were administered cyanamide (50 mg/kg, i.p.) 60 minutes prior to an acute injection of ethanol or saline and steroids were measured 45 minutes following the injections. (A) 3α,5α-THP levels were increased in the rat cerebral cortex after acute ethanol (2 g/kg, i.p.) administration and were not affected by treatment with an aldehyde dehydrogenase inhibitor. (B) Plasma alcohol levels were unaffected by aldehyde dehydrogenase inhibition while (C) plasma acetaldehyde levels were increased. *P < 0.001 compared to controls, n=6 in duplicate.