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. Author manuscript; available in PMC: 2011 Jul 2.
Published in final edited form as: Alcohol Clin Exp Res. 2008 Jul 24;32(10):1774–1781. doi: 10.1111/j.1530-0277.2008.00762.x

Fig. 4. Effects of pretreatment with 4-methylpyrazole and sodium azide on ethanol-induced 3α,5α-THP elevation.

Fig. 4

Animals were administered 4-methylpyrazole (200mg/kg, i.p.) or sodium azide (10 mg/kg, i.p.) prior to an acute injection of ethanol or saline and steroids were measured 45 minutes following injections. (A) 3α,5α-THP levels were increased in the rat cerebral cortex after acute ethanol (2 g/kg, i.p.) administration and were not affected by treatment with either inhibitor. (B) Plasma alcohol levels were increased in animals receiving the catalase inhibitor and (C) plasma acetaldehyde concentrations were decreased when catalase was inhibited. *P < 0.05 compared to controls, n=6 in duplicate.