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Reduction in RMSD between real and simulated light scattering over successive steps of optimization. (a) 2-parameter search of on- and off-rates for types A-D collectively. (b) 2-parameter search of on-rates for type A and types B-D bonds. (c) 3-parameter search of on-rates for type A, types B-C, and type D bonds. (d) 4-parameter search of on-rates for type A, type B, type C, and type D bonds.
