Table 1.

Summary of candidate gene SNP studies^†.

Study	Irradiated site	Subjects (n)	Result	Ref.
ATM
Hall et al.	Prostate	17	Association between ‘significant mutations’ with proctitis and cystitis	[11]
Iannuzzi et al.	Breast	46	Association between ‘significant’ SNPs with subcutaneous fibrosis and telangiectasia	[20]
Angele et al.	Breast	566	Association between SNPs rs1801516 and at nucleotides IVS22-77 and IVS48 + 238 with adverse radiation responses	[30]
Bremer et al.	Breast	1100	No association between protein truncation mutations with either acute or late radiation effects	[22]
Andreassen et al.	Breast	52	No association between any of the screened SNPs with altered breast appearance	[25]
Andreassen et al.	Breast	120	No association with risk of subcutaneous fibrosis for any of the screened SNPs	[27]
Cesaretti et al.	Prostate	37	Association between missense SNPs (cause substitution of the encoded amino acid) with rectal bleeding and erectile dysfunction	[13]
Andreassen et al.	Breast	41	Association between SNP rs1801516 with subcutaneous fibrosis	[26]
Damaraju et al.	Prostate	124	No association between genotyped SNPs with bladder and rectal toxicity	[15]
Cesaretti et al.	Prostate	108	Association between multiple SNPs with proctitis when the radiation dose to rectal tissue was quantified	[12]
Edvardsen et al.	Breast	462	Association between the rs1801516 SNP with telangiectasia and the rs1800058 SNP with pleural thickening and lung fibrosis	[23]
Ho et al.	Breast	131	Association between the codon 1853 SNP with fibrosis and telangiectasia	[59]
Meyer et al.	Prostate	721	No association between the codon 1054 SNP with either urinary morbidity or erectile dysfunction	[14]
Pugh et al.	Prostate	41	No association between screened SNPs with ‘high toxicity’	[16]
TGFB1
Andreassen et al.	Breast	41	Association between SNPs rs1800470 and rs1800469 with subcutaneous fibrosis	[24]
Quarmby et al.	Breast	103	Association between SNPs rs1800469 and rs1800470 with subcutaneous fibrosis	[60]
Andreassen et al.	Breast	52	Association between SNPs rs1800470 and rs1800469 with altered breast appearance	[25]
Andreassen et al.	Breast	120	No association for any of the screened SNPs with risk for subcutaneous fibrosis	[27]
Damaraju et al.	Prostate	124	No association between genotyped SNPs with bladder and rectal toxicity	[15]
Barnett et al.	Breast	778	No association between SNPs rs1800469 and rs1800470 with late radiation toxicity	[28]
De Ruyck et al.	Cervix/endometrium	218	Association between the SNPs at nucleotides −1.552delAGG, −509 and in codon 10 with development of late radiotherapy effects	[50]
Giotopulos et al.	Breast	167	Association between SNP rs1800469 with fibrosis	[31]
Peters et al.	Prostate	141	Association between SNPs rs1800469, rs1800471 and rs1982073 with erectile function Association between SNP rs1800469 with late rectal bleeding	[17]
Yuan et al.	Non-small-cell lung cancer	164	Association between SNP rs1982073 with radiation pneumonitis	[44]
SOD2
Andreassen et al.	Breast	41	Association between a SNP in codon 16 with subcutaneous fibrosis	[24]
Andreassen et al.	Breast	52	No association between genotyped SNPs with altered breast appearance	[25]
Andreassen et al.	Breast	120	No association for any of the screened SNPs with risk for subcutaneous fibrosis	[27]
Ahn et al.	Breast	446	No association between genotyped SNPs with acute skin toxicities	[33]
Kuptsova et al.	Breast	390	No association between genotyped SNPs with telangiectasia	[36]
XRCC1
Andreassen et al.	Breast	41	Association between a SNP in codon 399 with subcutaneous fibrosis	[24]
Moullan et al.	Breast	566	Association between codons 194 and 399 SNPs with adverse radiation effects	[61]
Andreassen et al.	Breast	52	No association between genotyped SNPs with altered breast appearance	[25]
Chang-Claude et al.	Breast	446	Association between codon 399 SNP with acute skin toxicities in patients with BMI >25	[32]
De Ruyck et al.	Cervix/endometrium	62	Association between a SNP in codon 194 with late effects	[49]
Andreassen et al.	Breast	120	No association for any of the screened SNPs with risk for subcutaneous fibrosis	[27]
Damaraju et al.	Prostate		No association between genotyped SNPs with bladder and rectal toxicity	[15]
Giotopoulos et al.	Breast	167	Association between a codon 399 SNP with telangiectasia	[31]
Chang-Claude et al.	Breast	409	No association between screened SNPs with telangiectasia	[37]
Mangoni et al.	Breast	87	Association between SNPs in codons 194 and 399 with increased acute skin reactions	[38]
Sun et al.	Lung	248	Association between SNPs rs2854510 and rs1001581 with survival	[48]
XRCC3
Andreassen et al.	Breast	41	Association between a SNP in codon 241 with subcutaneous fibrosis	[24]
Andreassen et al.	Breast	52	No association between genotyped SNPs with altered breast appearance	[25]
De Ruyck et al.	Cervix/endometrium	62	Association between a SNP at nucleotide IVS5-14 with late effects	[49]
Andreassen et al.	Breast	120	No association for any of the screened SNPs with risk for subcutaneous fibrosis	[27]
Damaraju et al.	Prostate		No association between genotyped SNPs with bladder and rectal toxicity	[15]
Popanda et al.	Breast	446	No association between SNP rs861539 in XRCC3 with acute skin toxicity	[29]
Chang-Claude et al.	Breast	409	No association between screened SNPs with telangiectasia	[37]
Werbrouck et al.	Head and neck	88	Association between SNP rs861539 with severe dysphasia	[62]
Mangoni et al.	Breast	87	Association between a SNP in codon 241 with increased acute skin reactions	[38]

^†Compilation of data for candidate genes in which SNPs were genotyped in a minimum of five studies.