Table 3.

CSP-exposed lungs—mean concentrations and dimensions of the fibers recovered from the lungs at each time point

	0 Day	1 Day	2 Days	7 Days	14 Days	30 Days	90 Days	181 Days	275 Days	365 Days
B07031 Lung samples group 2—CSP	Mean	Mean	Mean	Mean	Mean	Mean	Mean	Mean	Mean	Mean
No. of fibers evaluated	2568.5	2471.0	2461.0	2339.0	2216.0	2098.0	1382.0	1252.5	1348.0	1940.0
No. of total fibers (millions/lung)/(standard deviation)	39.57 (11.73)	42.26 (9.64)	30.44 (5.32)	38.71 (3.21)	22.27 (6.00)	13.44 (3.11)	6.13 (0.67)	5.53 (0.42)	3.15 (0.76)	3.43 (0.79)
No. WHO fibers (millions/lung)/(standard deviation)	9.78 (2.79)	9.82 (2.02)	7.91 (2.75)	7.84 (3.21)	3.91 (1.65)	1.76 (0.54)	0.53 (0.17)	0.43 (0.10)	0.51 (0.28)	0.49 (0.03)
No. WHO fibers of total fibers (%)	24.7%	23.2%	26.0%	20.2%	17.5%	13.1%	8.7%	7.8%	16.3%	14.2%
No. of fibers L > 20 µm (millions/lung/(standard deviation)	0.31 (0.11)	0.24 (0.05)	0.23 (0.03)	0.11 (0.02)	0.02 (0.00)	0.01 (0.01)	0.00–	0.001-*	0.001–*	0.001–*
Fibers L > 20 µm of total fibers (%)	0.8%	0.6%	0.7%	0.3%	0.1%	0.1%	0.0%	0.0%	0.0%	0.0%
No. of fibers L 5–20 µm (millions/lung)/(standard deviation)	9.47 (2.70)	9.58 (1.98)	7.69 (2.74)	7.72 (2.59)	3.89 (1.65)	1.75 (0.54)	0.53 (0.17)	0.43 (0.10)	0.51 (0.28)	0.49 (0.03)
Fibers L 5–20 µm of total fibers (%)	23.9%	22.7%	25.2%	20.0%	17.4%	13.0%	8.7%	7.8%	16.2%	14.2%
No. of fibers L ≤ 5 µm (millions/lung)/(standard deviation)	29.79 (9.08)	32.44 (7.81)	22.53 (3.21)	30.88 (7.29)	18.37 (4.61)	11.68 (2.72)	5.60 (0.52)	5.10 (0.45)	2.64 (0.51)	2.94 (0.80)
Fibers L ≤ 5 µm of total fibers (%)	75.3%	76.8%	74.0%	79.8%	82.5%	86.9%	91.3%	92.2%	83.7%	85.8%
Diameter range (µm)	0.01–1.3	0.01–1.0	0.01–2.0	0.01–2.0	0.01–1.0	0.01–1.0	0.01–1.0	0.01–0.5	0.01–0.6	0.01–0.5
Length range (µm)	1.0.90	1.0.90	1.0.110	1.0.80	0.5.32	0.5.40	0.5.20	0.5.21.0	0.5.25.0	0.5.25.0
Mean diameter (µm)	0.11	0.09	0.10	0.10	0.09	0.07	0.06	0.06	0.05	0.04
SD	0.11	0.09	0.10	0.10	0.09	0.08	0.07	0.06	0.05	0.04
Mean length (µm)	4.60	4.45	4.66	4.02	3.55	3.19	2.83	2.95	3.69	3.59
SD	3.77	3.50	3.80	3.10	2.47	2.27	1.95	1.87	2.46	2.39
GMD (µm)	0.06	0.06	0.07	0.07	0.06	0.05	0.04	0.04	0.04	0.03
GSD	2.82	2.46	2.53	2.47	2.45	2.19	2.31	2.20	2.04	1.86
GML (µm)	3.72	3.64	3.82	3.30	2.95	2.59	2.31	2.49	3.07	2.99
GSD	1.88	1.85	1.84	1.84	1.93	1.98	1.93	1.80	1.90	1.85
Length weighted arithmetic dia. (µm)	0.13	0.11	0.12	0.12	0.10	0.09	0.08	0.07	0.07	0.05
Length weighted geometric dia. (µm)	0.07	0.07	0.07	0.07	0.06	0.06	0.05	0.05	0.05	0.04
Mode diameter (µm)	0.03	0.03	0.03	0.03	0.03	0.03	0.03	0.03	0.03	0.03
Mode length (µm)	2.5	2.0	2.0	2.0	2.0	2.0	2.0	1.5	2.0	2.5
Median diameter (µm)	0.05	0.05	0.05	0.05	0.05	0.03	0.03	0.03	0.03	0.03
Median length (µm)	4.0	4.0	4.0	3.5	3.0	2.5	2.5	2.5	3.0	3.0
Aspect ratio Mean	101.4	92.6	93.2	75.7	76.0	76.4	80.5	84.3	101.3	117.9
Total length of fibers per lung (m)	182	188 142	156 79	43 17	16.3	11.6	12.3
Mass of fibers per lung in milligrams (density 2.6 g/cm3)	0.01	0.01	0.01	0.01	0.00	0.00	0.00	0.00	0.00	0.00
No. of particles evaluated	705.0	702.0	704.0	705.0	702.0	708.0	287.0	365.5	255.0	363.0
Mean no. of particles (millions/lung)	2.47	2.20	2.08	2.59	1.79	1.48	0.23	0.294	0.205	0.146
≤ 1 µm particles (millions/lung lobes)	2.06	2.08	1.98	2.46	1.75	1.48	0.23	0.292	0.205	0.145
> 1 µm to ≤ 3 µm particles (millions/lung lobes)	0.41	0.12	0.10	0.13	0.04	0.00	0.00	0.002	0.000	0.000
> 3 µm particles (millions/lung lobes)	0.00	0.00	0.00	0.00	0.00	0.00	0.00	0.000	0.000	0.000

^*Standard deviation not presented as only one fiber was observed with length 21 µm—181 Days and 25 µm—272 and 365 days.