Table 4.

Amosite-exposed lungs—mean concentrations and dimensions of the fibers recovered from the lungs at each time point

	0 Day	1 Day	2 Days	7 Days	14 Days	30 Days	90 Days	181 Days	275 Days	365 Days
B07031 Lung samples group 3—amosite	Mean	Mean	Mean	Mean	Mean	Mean	Mean	Mean	Mean	Mean
No. of fibers evaluated	2923.0	2883.0	2902.5	2881.5	2866.5	2860.5	2793.5	2811.0	2857.0	2844.5
No. of total fibers (millions/lung)/(standard deviation)	23.30 (8.04)	20.33 (2.79)	21.85 (5.41)	17.84 (4.62)	18.17 (4.65)	18.02 (3.13)	9.56 (3.15)	10.01 (1.99)	9.56 (0.93)	9.82 (1.25)
No. WHO fibers (millions/lung)/(standard deviation)	12.91 (4.02)	10.56 (1.48)	12.77 (3.21)	9.56 (3.00)	8.38 (2.03)	9.33 (1.54)	4.98 (1.68)	5.46 (1.68)	5.76 (0.93)	5.78 (0.96)
No. WHO fibers of total fibers (%)	55.4%	51.9%	58.4%	53.6%	46.1%	51.7%	52.1%	54.5%	60.2%	58.9%
No. of fibers L > 20 µm (millions/lung/(standard deviation)	2.74 (0.81)	2.24 (0.41)	2.81 (0.56)	1.98 (0.58)	1.63 (0.37)	1.98 (0.28)	1.10 (0.56)	1.11 (0.43)	1.33 (0.23)	1.39 (0.19)
Fibers L > 20 µm of total fibers (%)	11.8%	11.0%	12.9%	11.1%	8.9%	11.0%	11.5%	11.1%	14.0%	14.1%
No. of fibers L 5–20 µm (millions/lung)/(standard deviation)	10.16 (3.40)	8.32 (1.18)	9.96 (2.72)	7.58 (2.45)	6.76 (1.71)	7.34 (1.31)	3.88 (1.14)	4.35 (1.26)	4.42 (0.72)	4.39 (0.81)
Fibers L 5–20 µm of total fibers (%)	43.6%	40.9%	45.6%	42.5%	37.2%	40.7%	40.6%	43.4%	46.3%	44.7%
No. of fibers L ≤ 5 µm (millions/lung)/(standard deviation)	10.40 (4.31)	9.77 (2.24)	9.08 (2.41)	8.28 (2.90)	9.79 (3.24)	8.70 (2.33)	4.58 (1.57)	4.55 (0.42)	3.80 (0.48)	4.04 (0.55)
Fibers L ≤ 5 µm of total fibers (%)	44.6%	48.1%	41.6%	46.4%	53.9%	48.3%	47.9%	45.5%	39.8%	41.1%
Diameter range (µm)	0.03–3.0	0.03–3.0	0.02–3.0	0.02–2.0	0.03–1.5	0.03–1.5	0.03–1.6	0.03–1.4	0.03–2.0	0.03–1.5
Length range (µm)	0.5–110	0.6–110	0.7–100	0.6–125	0.8–90.0	0.6–105	1.0–110	0.5–105.0	0.7–95.0	1.0–105.0
Mean diameter (µm)	0.35	0.34	0.37	0.34	0.33	0.34	0.36	0.36	0.33	0.30
SD	0.21	0.22	0.26	0.19	0.19	0.18	0.21	0.19	0.19	0.18
Mean length (µm)	9.54	9.23	10.16	9.22	8.03	9.18	8.95	8.85	10.66	10.78
SD	10.11	10.16	10.68	10.10	9.01	9.76	9.78	9.37	10.71	11.59
GMD (µm)	0.29	0.28	0.29	0.27	0.27	0.29	0.29	0.30	0.27	0.23
GSD	1.84	1.99	2.06	2.02	2.00	1.85	2.11	1.98	2.11	2.19
GML (µm)	6.23	5.87	6.50	5.87	5.05	5.92	5.65	5.75	6.94	6.81
GSD	2.65	2.65	2.72	2.64	2.72	2.63	2.68	2.64	2.59	2.71
Length weighted arithmetic dia. (µm)	0.43	0.43	0.47	0.41	0.42	0.41	0.46	0.44	0.42	0.39
Length weighted geometric dia. (µm)	0.33	0.32	0.34	0.32	0.32	0.33	0.35	0.33	0.31	0.28
Mode diameter (µm)	0.40	0.40	0.20	0.40	0.20	0.40	0.30	0.35	0.35	0.35
Mode length (µm)	2.0	2.0	2.0	1.5	2.0	2.0	2.0	2.0	2.0	1.5
Median diameter (µm)	0.33	0.30	0.30	0.30	0.30	0.33	0.35	0.35	0.30	0.30
Median length (µm)	6.0	6.0	7.0	6.0	4.5	6.0	5.5	6.0	7.0	7.0
Aspect ratio mean	32.19	32.51	34.51	33.43	28.76	30.70	29.57	30.6	37.6	42.1
Total length of fibers per lung (m)	224.7	189.6	223.3	168.8	147.7	166.8	88.1	92.6	103.2	106.5
Mass of fibers per lung in milligrams (density 2.6 g/cm3)	0.15	0.13	0.19	0.10	0.09	0.10	0.06	0.06	0.06	0.06
No. of particles evaluated	357.0	297.5	201.5	317.5	379.0	317.0	465.5	287.0	201.0	163.0
Mean no. of particles (millions/lung)	1.38	0.93	0.79	0.87	0.85	0.87	0.72	0.440	0.369	0.316
≤ 1 µm particles (millions/lung lobes)	1.14	0.72	0.60	0.83	0.82	0.84	0.68	0.375	0.340	0.305
> 1 µm to ≤ 3 µm particles (millions/lung lobes)	0.23	0.19	0.19	0.04	0.02	0.02	0.04	0.065	0.029	0.012
> 3 µm particles (millions/lung lobes)	0.01	0.01	0.00	0.00	0.00	0.01	0.00	0.000	0.000	0.000

Clearance half-times of fibers.