Table 3.

Correlations of cognitive and MSFC measures with physical and mental MSQOL-54 and EDSS at screening (Day 0) and Month 24

	MSQOL-54 Physical		MSQOL-54 Mental		EDSS
	Day 0	Month 24	Day 0	Month 24	Day -60	Month 24
Power of Attention	0.14 p = 0.4371	0.21 p = 0.2707	0.1 p = 0.5311	0.07 p = 0.6964	0.62 p < 0.0001	0.5 p = 0.0023
Continuity of Attention	0.16 p = 0.2395	0.34 p = 0.0755	0.04 p = 0.8276	0.04 p = 0.8132	0.43 p = 0.0062	0.53 p = 0.001
Quality of working Memory	0.06 p = 0.733	0.35 p = 0.0598	0.14 p = 0.3742	0.41 p = 0.017	0.48 p = 0.0018	0.37 p = 0.0276
Quality of Episodic Memory	0.01 p = 0.9654	0.64 p = 0.0034	0.02 p = 0.9028	0.6 p = 0.0029	0.33 p = 0.0422	0.35 p = 0.0892
Speed of Memory	0.18 p = 0.3038	0.42 p = 0.0239	0.02 p = 0.8819	0.19 p = 0.2949	0.45 p = 0.0035	0.43 p = 0.0092
CDR composite	0.19 p = 0.2711	0.47 p = 0.0412	0.13 p = 0.4107	0.25 p = 0.2676	0.59 p < 0.0001	0.61 p = 0.0015
DSST	0.24 p = 0.1618	0.27 p = 0.2395	0.09 p = 0.5748	0.06 p = 0.7577	0.47 p = 0.0028	0.76 p < 0.0001
Timed 25-FWT	0.35 p = 0.0373	0.27 p = 0.154	0.15 p = 0.343	0.07 p = 0.6786	0.0 p = 0.9764	0.49 p = 0.002
9-HPT	0.0 p = 0.9896	0.08 p = 0.6629	0.23 p = 0.12	0.08 p = 0.652	0.55 p = 0.0001	0.53 p = 0.0003
PASAT 3"	0.03 p = 0.8805	0.16 p = 0.411	0.07 p = 0.6612	0.06 p = 0.7142	0.4 p = 0.0071	0.42 p = 0.0091
MSFC	0.17 p = 0.3352	0.19 p = 0.3328	0.02 p = 0.9241	0.12 p = 0.4834	0.43 p = 0.0044	0.56 p = 0.0003

MSFC, Multiple Sclerosis Functional Composite; MSQOL-54, Multiple Sclerosis-54 Quality of Life; EDSS, Expanded Disability Status Scale; CDR, Cognitive Drug Research, DSST, Digit Symbol Substitution Test; Timed 25-FWT, Timed 25 Foot Walk Test; 9-HPT, 9 Hole Peg Test, PASAT 3", Paced Auditory Serial Addition Test 3 sec. Correcting for multiplicity p-values are statistically significant at p < 0.0008.