Table 4.
Correlations between CDR measures and DSST, MSFC component scores and MSFC at baseline
| Power of Attention | Continuity of Attention | Quality of working memory | Quality of episodic memory | Speed of memory | CDR composite | |
|---|---|---|---|---|---|---|
| DSST | 0.61 p < 0.0001 |
0.49 p = 0.0009 |
0.33 p = 0.0333 |
0.25 p = 0.1068 |
0.55 p = 0.0001 |
0.7 p < 0.0001 |
| Timed 25-FWT | 0.18 p = 0.236 |
0.23 p = 0.1465 |
0.31 p = 0.0424 |
0.14 p = 0.3678 |
0.15 p = 0.3217 |
0.17 p = 0.2673 |
| 9-HPT | 0.55 p = 0.0001 |
0.32 p = 0.0368 |
0.12 p = 0.3767 |
0.16 p = 0.3035 |
0.4 p = 0.0076 |
0.48 p = 0.001 |
| PASAT 3" | 0.6 p < 0.0001 |
0.31 p = 0.0431 |
0.2 p = 0.2092 |
0.17 p = 0.2692 |
0.35 p = 0.0209 |
0.49 p = 0.0009 |
| MSFC | 0.61 p = 0.0001 |
0.39 p = 0.0095 |
0.29 p = 0.0549 |
0.09 p = 0.5752 |
0.42 p = 0.0056 |
0.52 p = 0.0003 |
CDR, Cognitive Drug Research; DSST, Digit Symbol Substitution Test; MSFC, Multiple Sclerosis Functional Composite; Timed 25-FWT, Timed 25-Foot Walk Test; 9-HPT, 9 Hole Peg Test, PASAT 3", Paced Auditory Serial Addition Test 3 sec. Correcting for multiplicity p-values are statistically significant at p < 0.0017.