Table 1.
Outcomes and treatment of the 16 patients with active leg ulceration
| Patient no. | DAS-28 at ulcer development | DAS-28 at healing or most recent visit | Remission (+/−) | Medication
|
Ulcer outcome | Follow-up duration (months) | Total time to ulcer healing | Time to ulcer healing after starting DMARD or anti-TNF therapy | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
| HCQ | Non-biol DMARD | Steroid | Anti-TNF | ||||||||
| 1 | 6.99 | 7.47 | − | + | + | + | − | Not healed | 20.4 | − | − |
| 2 | 1.47 | 1.44 | + | + | + | + | + | Not healed | 30.6 | − | No response |
| 3 | 2.02 | 1.79 | + | + | + | − | + | Healed | 22.3 | 22.3 | 4 |
| 4 | 7.52 | 2.86 | + | − | + | − | + | Healed | 16.3 | 16.3 | 4 |
| 5 | 5.89 | 2.73 | + | + | + | − | − | Not healed | 19.0 | − | − |
| 6 | 3.03 | 3.03 | + | + | + | + | + | Amputated | 9.8 | 9.8 | 1 |
| 7 | 4.07 | 2.30 | + | − | + | − | − | Not healed | 5.7 | − | − |
| 8 | 3.16 | 3.50 | − | − | + | + | − | Not healed | 1.5 | − | − |
| 9 | 7.53 | 7.75 | − | + | − | − | − | Not healed | 45.7 | − | − |
| 10 | 1.40 | 1.86 | + | + | + | − | + | Healed | 10.6 | 10.6 | 1 |
| 11 | 2.46 | 2.46 | + | − | − | − | − | Not healed | 2.0 | − | − |
| 12 | 2.91 | 2.55 | + | − | + | + | − | Healed | 21.1 | 21.1 | 3.5 |
| 13 | 2.80 | 1.59 | + | + | + | + | − | Healed | 116.3 | 116.3 | 116.3 |
| 14 | 3.62 | 3.62 | − | − | + | − | − | Died | 3.1 | − | − |
| 15 | 2.67 | 2.60 | + | − | − | + | − | Not healed | 17.0 | − | − |
| 16 | 7.99 | 7.99 | − | − | + | − | − | Not healed | 3.0 | − | − |
HCQ hydroxychloroquine, Non-biol DMARD non-biologic disease modifying antirheumatic drug, Anti-TNF anti-tumor necrosis factor-α agent