Table 2.
Overall study population | Participants with CD4 count <200 cells/μl | Participants staged at WHO clinical stage 3 or 4 | |||||||
---|---|---|---|---|---|---|---|---|---|
Prevalence % (95% confidence interval), n | Cape Town (n = 157) | Mumbai (n = 149) | P | Cape Town (n = 120) | Mumbai (n = 84) | P | Cape Town (n = 99) | Mumbai (n = 83) | P |
Overall HIV ocular disease | 12.1% (7.4–18.3) | 17.5% (11.7–24.5) | 0.19 | 13.3% (7.8–20.7) | 23.8% (15.2–34.3) | 0.05 | 15.5% (8.7–23.8) | 27.2% (18.4–38.6) | 0.05 |
19 | 26 | 16 | 20 | 15 | 23 | ||||
Overall retinal opportunistic infections† | 2.6% (0.7–6.4) | 11.4% (6.8–17.6) | 0.003 | 2.5% (0.5–7.1) | 15.5% (8.5–25.0) | 0.001 | 4.0% (1.1–10.0) | 19.3% (11.4–29.4) | 0.001 |
4 | 17 | 3 | 13 | 4 | 16 | ||||
Cytomegalovirus retinitis (CMVR) | 1.3% (0.1–4.5) | 8.7% (4.7–14.4) | 0.003 | 0.8% (0.02–4.5) | 11.9% (5.8–20.8) | 0.001 | 2.0% (0.2–7.1) | 14.4% (7.7–23.9) | 0.002 |
2 | 13 | 1 | 10 | 2 | 12 | ||||
Ocular TB and toxoplasmosis | 1.3% (0.1–4.5) | 2.7% (0.7–6.7) | 0.38 | 1.6% (0.2–5.9) | 3.6% (0.7–10.0) | 0.39 | 2.0% (0.2–7.1) | 4.8% (1.3–11.8) | 0.29 |
2 | 4 | 2 | 3 | 2 | 4 | ||||
Other conditions | |||||||||
Optic neuropathy | 3.8% (1.4–8.1) | 2.0% (0.4–5.8) | 0.5 | 4.2% (1.4–9.5) | 0 (0) | 0.08 | 4.0% (1.0–10.0) | 2.4% (0.3–8.4) | 0.69 |
6 | 3 | 5 | 4 | 2 | |||||
HIV retinopathy | 5.1% (2.2–9.8) | 4.7% (1.9–9.4) | 0.87 | 5.0% (1.9–10.6) | 8.3% (3.4–16.4) | 0.34 | 5.1% (1.7–11.4) | 6.0% 2.0–13.5 | 0.77 |
8 | 7 | 6 | 7 | 5 | 5 |
*NB – participants could have more than one condition, so values within subsets may not reflect overall total.
Retinal opportunistic infections: CMVR, choroidal TB, toxoplasmosis.