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. Author manuscript; available in PMC: 2012 Jan 1.
Published in final edited form as: J Immunol. 2011 May 25;187(1):325–336. doi: 10.4049/jimmunol.1003523

Figure 3. The A/J and B6 haplotypes at Idd10 provide equivalent protection from type 1 diabetes.

Figure 3

The frequency of diabetes was determined in the indicated number (N) of females in each cohort. A, NOD, NOD.B6 Idd10, NOD.CAST Idd10 and NOD.A/J Idd10 congenic mice were bred using breeders homozygous for the NOD, B6, CAST and A/J haplotypes, respectively. B, NOD and NOD.A/J Idd10 congenic mice were intercrossed and the resulting F1 progeny intercrossed to produce an F2 generation. Mice were genotyped at Idd10 following the development of diabetes or at the end of the 196 day observation period. C, NOD and NOD.CAST Idd10 congenic mice were used to generate an F2 cohort for assessing the development of diabetes as described in B.