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SHARP depletion in normal myoblasts recapitulates DM1 RNA steady-state changes. Real-time PCR analysis shows that decreased levels of SHARP in normal myoblasts results in reduced steady-state levels in 25 of the 39 RNAs examined. Error bars (±) represent standard deviation (n=3). P-values determined by paired Student's t-test are listed in supplementary Table S5 online. DM1, myotonic dystrophy; SHARP, SMART/HDAC1-associated repressor protein.
