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. 2011 Apr 4;2:64. doi: 10.3389/fmicb.2011.00064

Figure 2.

Figure 2

Targeting of host cell PI metabolism by L. pneumophila. (1) Depending on the model system, uptake into the host cell may require PI3K signaling (Khelef et al., 2001; Weber et al., 2006; Tachado et al., 2008; Charpentier et al., 2009; Peracino et al., 2010). (2) To properly establish the LCV, L. pneumophila interferes with host vesicle trafficking. Changes in the composition of PIs at the LCV might contribute to altered trafficking (Weber et al., 2006, 2009b; Isberg et al., 2009). (3) Changes in the PI levels at the vacuole may help L. pneumophila to avoid the endocytic pathway (Lindmo and Stenmark, 2006; Weber et al., 2006, 2009a). (4) Throughout intracellular growth, PIs at the LCV likely provide scaffolding for both L. pneumophila translocated proteins and host proteins (Weber et al., 2006, 2009b; Ragaz et al., 2008; Brombacher et al., 2009).