Table 2.

Functional category of significantly changed proteins after HI injury

Protein Name	Change	Function
Cortical Development
Tyrosine 3-monooxygenase/tryptophan 5- monooxygenase activation protein (14-3-3 ε)	Decrease	essential for normal brain development and neuronal migration
TUC-2: Dihydropyrimidinase related protein-2 (DRP-2) Turned on after division, 64kDa protein(TOAD-64) Collapsin response mediator protein 2 (CRMP-2)	Decrease	axon guidance and outgrowth
Metabolism Enzymes
Phosphoglycerate kinase-1	Increase	enzyme involved in the glycolytic pathway
Isocitrate dehydrogenase 1 (NADP+)	Increase	enzyme in Kreb circle
Glyceraldehyde-3-phosphate dehydrogenase	Increase	enzyme involved in the glycolytic pathway
Translation Factor
Eukaryotic translation enlongation factor 2	Increase	Protein translation
Neurotransmission
Dopamine- and cAMP-regulated phosphoprotein	Increase	Major target for dopamine activated adenylyl cyclase; crucial mediator of the biochemical, electrophysiological, transcriptional, and behavioral effects of dopamine
Synuclein, alpha	Increase	Involved in multiple steps of dopamine metabolism, including synthesis, storage, release, and uptake.