Table 1.
Characteristics of EAE induced by different T cell subsets
| Th1 | Th17 | Th9 | |
|---|---|---|---|
| Severity | +++ | +++ | ++ |
| Effector cytokines | IFN-γ |
IL-17, IFN-γ, IL-22, IL-21 |
IFN-γ, IL-9, IL-10, IL-4, IL-17 |
| Lesion localization |
Spinal cord, brain |
Cerebellum/brain stem, spinal cord |
Spinal cord, brain |
| Clinical signs | Classical | Atypical and classical | Classical |
| Secondary cells | Macrophages | Neutrophils, B cells?, macrophages |
? Mast cells? |
| Special features | Lymphoid-follicle like structures |
Peripheral neuritis, extensive demyelination |