Table 2.

Periplasmic proteins of L. pneumophila associated with virulence and survival.

Protein	Molecular function	Role in infection/required for	Reference
Copper–zinc–superoxide dismutase	Detoxification of superoxide radicals	Stationary growth survival	St John and Steinman (1996)
KatA	Degradation of H2O2	Optimal infection of macrophages and amoeba (optimal function of the Dot/Icm apparatus)	Bandyopadhyay et al. (2003)
IcmX	Putative DNA polymerase (POLBc superfamily)	Establishment of the Legionella-containing vacuole, pore formation in macrophage cell membranes	Matthews and Roy (2000)