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. 2011 May 19;286(27):23938–23949. doi: 10.1074/jbc.M111.237065

FIGURE 5.

FIGURE 5.

LXR activation increases saturated and monounsaturated fatty acids whereas FXR activation reduces it. CVCs were treated with T090 (3 μm), INT-747 (3 μm), and adenovirus expressing VP16-LXRs or VP16-FXR for 14 days in the presence of high (2.0 mm) phosphate. Fatty acid levels were analyzed with gas chromatography. A, fatty acid levels in CVCs treated with T090 for 14 days. B, time course of fatty acid changes by T090 treatment. C, fatty acid levels in CVCs treated with an adenovirus expressing either VP16-LXRα or VP16-LXRβ. D, fatty acid levels in CVCs treated with either INT-747 at 3 μm or an adenovirus expressing VP16-FXR. CVCs were treated with adenoviruses at a MOI of 40. After 12 h of adenovirus treatment, the media was replaced with DMEM containing 15% FBS and 2.0 mm phosphate for 14 days. *, p < 0.01 versus vehicle treatment; #, p < 0.01 versus Ad-empty treatment (Empty).