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. 2011 May 19;286(27):23938–23949. doi: 10.1074/jbc.M111.237065

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© 2011 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 9. — Stearate metabolism in vascular calcification. A, calcium content in CVCs treated with TOFA (3 μm, ACC inhibitor, CAY10566 (1 μm, SCD1 inhibitor), adenovirus expressing SCD1 (Ad-SCD1, MOI 40), and triacsin C (5 μm, acyl-CoA synthetase inhibitor) for 10 days in the presence of T090 (5 μm) and high phosphate (2.3 mm). B, calcium content in CVCs treated with CAY10566 (1 μm, SCD1 inhibitor), Adenovirus expressing SCD1 (Ad-SCD1, MOI 40) and triacsin C (5 μm, acyl-CoA synthetase inhibitor) for 5 days in the presence of T090 (5 μm) and high phosphate (2.3 mm). C, proposed mechanism for the pro-calcific effect of LXR activation and the anti-calcific effect of FXR activation.