Biological processes affected by effectors analyzed in this study. S. typhimurium effectors binding to host cell targets suggest a set of biological contexts to be influenced by infection. SseG (G) and SspH2 (H2) bind, respectively, to Caprin-1 and Bub3/AH receptor-interacting protein (AIP)/Sgt-1, host proteins influencing cell cycle control. SseF (F), SseG, SseL (L), and SseJ (J) target proteins located at desmosomes or focal adhesions, suggesting a role in the regulation of cell attachment. SspH1 (H1), SspH2, and SseL target PKN1, Sgt1, and OSBP, respectively, arguing for a possible role in the regulation of innate immunity.