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. 2011 May 18;286(27):24170–24179. doi: 10.1074/jbc.M110.212274

FIGURE 3.

FIGURE 3.

Effect of Src kinase inhibition on platelet aggregation and secretion mediated by the simultaneous stimulation of G12/13 and Gi/Gz pathways. Washed human platelets were preincubated at 37 °C with DMSO (vehicle), 10 μm PP1, 10 μm PP2, or 10 μm PP3 for 5 min prior to platelet stimulation with either (A) 60 μm YFLLRNP + 100 nm 2-MeSADP + MRS2179 (100 μm) or (B) YFLLRNP (60 μm) + epinephrine (10 μm), and platelet aggregation and ATP secretion were measured. The data shown are representative of at least three experiments.