FIGURE 1.

Models of Dnmt3a-C/3L-C heterotetramer and Dnmt3a-C oligomers in complex with DNA. A, model of the Dnmt3a/Dnmt3L C-terminal domain tetramer, colored in green for Dnmt3a-C and in cyan for Dnmt3L-C. The cofactor S-adenosyl-l-methionine is shown in yellow and the modeled DNA in blue. The close up of the FF and RD interfaces is shown with the relevant amino acid residues labeled. B and C, modeling of Dnmt3a-C oligomers formed by the interaction of FF-dimers via their RD interface. The figure shows a hexameric complex as an example; the three FF-dimeric building blocks are colored light green and dark olive green. The two DNA molecules bound at the RD interfaces in the Dnmt3a-C hexamer are oriented roughly in parallel. Panel B shows a view along the axis of the bound DNA molecules, panel C shows a view perpendicular to the axis of the Dnmt3a oligomer.