FIGURE 3.

Structure of TL in LPS micelles. Panel A, superposition of backbone atoms (N, C^α, C′) of the 20 lowest energy conformers of dimeric TL in the context of LPS micelles. Panel B, a representative structure of the anti-parallel dimer of TL showing side chain orientation and backbone topology. Panel C, a space-filling representation of the side chain-side chain contacts between two helical monomers of TL involving aromatic residues Trp⁴, Phe⁵, Phe⁸, and aliphatic residue Leu⁹. Panel D, electrostatic potential surface of the dimeric structure of TL in LPS micelles showing the distribution of charge and non-polar residues. Panel E, disposition of side chains of aromatic and aliphatic amino acid residues and cationic and polar amino acid residues of the dimeric structure of TL. Backbone and side chain atoms of the dimer are represented as a stick.