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. 2011 May 24;286(27):24426–24433. doi: 10.1074/jbc.M111.251983

FIGURE 6.

FIGURE 6.

Overexpression of RNF170FLAG or *RNF170FLAG modulates IP3 receptor down-regulation. Rat1 cell clones stably expressing either RNF170 FLAG, *RNF170FLAG, or empty vector were incubated without or with 10 nm ET1 for 1 h, and immunoreactivity of IP3R1, erlin2 (loading control), or FLAG epitope (to monitor RNF170 FLAG or *RNF170FLAG expression) was assessed. Data shown are representative of at least six vector-, RNF170 FLAG-, or *RNF170FLAG-expressing clones. *, p < 0.05 comparing IP3R1 immunoreactivity without or with ET1 for each clone.