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. 2011 May 19;286(27):24443–24450. doi: 10.1074/jbc.M110.197525

FIGURE 4.

FIGURE 4.

Effect of the G3036E Cbl mutant on RTK signaling and ancillary proteins. A, immunoprecipitation (IP) analysis showing that the G306E Cbl mutant increased PDGFRα and FGFR2 phosphorylation in clonal hMSCs. B, Western blot analysis showing that the G306E Cbl mutant increased ERK1/2 and PI3K, but not Akt phosphorylation in clonal hMSCs. C–F, Western blot (WB) analysis showing increased Cbl-b (C) but unchanged Grb2 (D), phospho-Spy2 (E) and phospho-FRS2α (F) in clonal hMSCs expressing the G306E Cbl mutant. IgG served as internal control.