Figure 7.

Mutually exclusive patterns of promoter DNA methylation and histone H3K4me3 marks in LNCaP cells. Integration of M-NGS DNA methylation data with H3K4me3 ChIP-seq data indicates that DNA methylation and H3K4me3 may be present on the same gene promoter but remain nonoverlapping, adjacent modifications in these promoters. Each row represents a unique promoter region, ±1500 bp flanking the transcription start site (white dotted line) at 100-bp window size. The CpG island location is indicated in red in the first column. The second column represents histone H3K4me3 marks (blue), and the third column (yellow) depicts DNA methylation observed in the corresponding location in LNCaP. Superimposed data are displayed in the fourth column.