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. 2011 Jul;13(7):725–735. doi: 10.1093/neuonc/nor053

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© The Author(s) 2011. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

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Fig. 6. — Cell viability, apoptosis, and autophagy rate in human HGG cells after GADD153 complementary DNA overexpression. Bar graphs showing a significant decrease in cell viability after overexpression of GADD153 complementary DNA in U87 (A) and T98G (E) HGG cells. A significant increase in apoptotic (B and F) and autophagic (C and G) rate was also seen. *P < .05, Student's t-test compared with vector. Western blotting showing increased expression of CHOP/GADD153, apoptosis (cleaved caspase-3), and autophagy (LC3II) markers in U87 (D) and T98G (H) cells after transient transfection of CHOP/GADD153.