Table 2.
Allele and genotype distributions of MTNR1B polymorphisms in GDM and control subjects
| Loci | Genotype | RAF | N (%) | Referent | Co-dominant | Dominant | Recessive | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| GDM | Controls | GDM | Controls | OR(95%CI) | Pcor. | OR(95%CI) | Pcor. | OR(95%CI) | Pcor. | OR(95%CI) | Pcor. | ||
| CC | 235(25.9%) | 313(32.2%) | 1 | ||||||||||
| CT | 433(47.6%) | 455(46.8%) | 1.33 | 0.1 | 1.3 | 0.0008 | 1.44 | 0.008 | 1.42 | 0.03 | |||
| rs1387153 | 0.503 | 0.444 | (1.06-1.66) | (1.14-1.49) | (1.17-1.78) | (1.14-1.78) | |||||||
| TT | 241(26.5%) | 204(21.0%) | 1.29 | 0.001 | |||||||||
| (1.13-1.47) | |||||||||||||
| CC | 217(23.9%) | 294(30.4%) | 1 | ||||||||||
| CG | 435(47.9%) | 469(48.6%) | 1.31 | 0.2 | 1.35 | 0.0001 | 1.46 | 0.006 | 1.54 | 0.001 | |||
| rs10830963 | 0.521 | 0.453 | (1.04-1.65) | (1.18-1.54) | (1.18-1.81) | (1.23-1.92) | |||||||
| GG | 256(28.2%) | 203(21.0%) | 1.34 | 0.0001 | |||||||||
| (1.18-1.53) | |||||||||||||
P values were corrected for multiple testing by multiplying the number of tests (10 tests, 2 SNPs × 5 tests (2 referent, co-dominant, dominant and recessive models)) (Bonferroni correction). RAF, risk allele frequency.