Table 1.

Nomenclature from Equations 2 and 3

Symbol	definition	units
I	Plasma insulin concentration	mU/L
Q	Interstitial insulin concentration	mU/L
UN	Endogenous insulin production rate profile	mU/L/min
UX	Exogenous insulin bolus	mmol
nK	Renal clearance of plasma insulin	1/min
nL	Hepatic clearance of plasma insulin	1/min
nC	Insulin clearance to cells	1/min
nI	Transition of insulin between plasma and interstitium	L/min
αI	Saturation of hepatic insulin clearance	L/mU
xL	First pass clearance of insulin	1
VP	Distribution volume of plasma insulin	L
VQ	Distribution volume of interstitial insulin	L