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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Ultrasound Med Biol. 2011 Jun 8;37(8):1259–1270. doi: 10.1016/j.ultrasmedbio.2011.04.019

Figure 5.

Figure 5

Macrophotographs showing gross tissue effects in the formalin-fixed brains from the two examples shown in Figure 3. With ketamine/xylazine (A and B), BBB disruption, as evidenced by leakage of Trypan blue, was observed at the target depth and on the brain surface. Regions with extensive extravasation of erythrocytes were produced by sonication at 4.1W (left), and additional blue-stained regions were observed areas at the peripheral regions and on the brain midline (arrows). With isoflurane/oxygen (C and D), the Trypan blue leakage was substantially less, and the extravasated erythrocytes were not seen. (bar: 5 mm)