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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Cancer Res. 2011 Apr 25;71(13):4380–4391. doi: 10.1158/0008-5472.CAN-11-0308

Figure 1. HER2 expression mediates an inflammatory response and expression of IL-6 across multiple cell types.

Figure 1

A) Microarray heat map of significantly dysregulated mRNA inflammatory genes (A) and miRNAs (B) (N=3–5, MOI=150, 16hpi). C) Quantitative real-time PCR analysis of inflammatory genes in Ad infected HMECs (as in A)) and HER2wt, HER2ki, and control stably infected cell lines (N=5, MOI=150, 16hpi). In all heat maps, red represents high expression and green represents low expression. D) IL-6 secretion from stably infected MCF-10a and MCF-7 cells (N=4). E) IL-6 secretion from HER2-stable MCF-10a cells treated with lapatinib, a lapatinib analog, or control vehicle (10 μM assessed at 24 hours post-treatment, N=4). E) IL-6 secretion from stably infected NIH/3T3 and 4T1 cells (N=4). For C–E, N=5, bars indicate SD, while * indicates a p<.05 from controls, and ** indicates a p<.01 from controls.