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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Cancer Res. 2011 Apr 25;71(13):4380–4391. doi: 10.1158/0008-5472.CAN-11-0308

Figure 2. Transcriptional regulation of HER2 mediated IL-6 expression.

Figure 2

A) Kinase inhibition (10 μM) of IL-6 secretion in MCF-10a-HER2 cells (N=3, 24 hours post-treatment, bars represent SD). B and C) NF-kB, AP-1, and C/EBP activity in MCF-10a and MCF-10a-HER2 cells (B) or NIH/3T3 or NIH/3T3-HER2 cells (C). In all samples, luciferase expression measured at 24 hours post-transfection (hpt), N=4, bars represent SD. D) NF-kB inhibition of IL-6 secretion in MCF-10a-HER2 cells (N=4, 24hpt, bars represent SD). Where indicated * and ** represent p<.05 and p<.01 respectively in comparison to controls. E) Schematic diagram of the signaling pathways regulating HER2-induced transcriptional upregulation of IL-6.