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. Author manuscript; available in PMC: 2012 Jul 1.

Published in final edited form as: J Thromb Haemost. 2011 Jul;9(7):1308–1317. doi: 10.1111/j.1538-7836.2011.04331.x

APC ameliorates post-ischemic cardiac dysfunction and injury. (A) The heart rate and left ventricular pressure during baseline perfusion and post-ischemic reperfusion with or without administration of APC derivatives were assessed as described under Methods. Values are means ± S.E., n=4–6 hearts for each group. *p<0.05 APC vs. Con; †p<0.05 APC-2Cys vs. Con during reperfusion. (B) The ratio of infarct size of isolated mouse hearts after 2h reperfusion with APC derivatives or vehicle (Con). Values are means ± S.E., n=4 per group. *p<0.05 vs. Con. (C) Phosphorylation of AMPK and ACC and (D) activation of AMPKα₁ (left panel) and AMPKα₂ (right panel) during ex vivo ischemia reperfusion with or without APC. Values are means ± S.E., n=4 per group, *p< 0.05 vs. basal control, †p<0.05 vs. I/R control.

APC ameliorates post-ischemic cardiac dysfunction and injury. (A) The heart rate and left ventricular pressure during baseline perfusion and post-ischemic reperfusion with or without administration of APC derivatives were assessed as described under Methods. Values are means ± S.E., n=4–6 hearts for each group. *p<0.05 APC vs. Con; †p<0.05 APC-2Cys vs. Con during reperfusion. (B) The ratio of infarct size of isolated mouse hearts after 2h reperfusion with APC derivatives or vehicle (Con). Values are means ± S.E., n=4 per group. *p<0.05 vs. Con. (C) Phosphorylation of AMPK and ACC and (D) activation of AMPKα₁ (left panel) and AMPKα₂ (right panel) during ex vivo ischemia reperfusion with or without APC. Values are means ± S.E., n=4 per group, *p< 0.05 vs. basal control, †p<0.05 vs. I/R control.