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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: Cancer Res. 2011 Jun 28;71(13):4329–4333. doi: 10.1158/0008-5472.CAN-11-0640

Fig. 1.

Fig. 1

A, schematic diagram indicating FoxM1 expression is stimulated by oncogenes and growth factors and inhibited by p53. Rb and p19Arf inhibit activity of FoxM1. B, schematic diagram indicating FoxM1 stimulates expression of genes involved in cell division, attenuation of oxidative stress, tumorigenicity and drug resistance. A new study (20) demonstrated that FoxM1 could stimulate expression of genes involved in various steps of tumor metastasis, including epithelial to mesenchymal-like transition, cell-migration and pre-metastatic niche formation.