Table 3.

Top-associated SNPs from the genome-wide analysis in UK, US and Spanish cases and controls together with conditioning analysis on these groups

Top SNPs	UK (N = 74/306*)				US (N = 51/306)				Spanish (N = 46/160)				Test of heterogeneity (p-value)	MAF (case vs control)
	p- value	OR (95% CI)	p-value conditioned on rs9274407	p-value conditioned on rs3135388	p- value	OR (95% CI)	p-value conditioned on rs9274407	p-value conditioned on rs3135388	p- value	OR (95% CI)	p-value conditioned on rs9274407	p-value conditioned on rs3135388		nw-EU**	Spanish
rs9274407	1.7×10−8	3.3 (2.2 – 5.0)	NA	7.3×10−5	7.9×10−6	3.0 (1.9 – 4.8)	NA	0.12	0.0019	2.9 (1.5 – 5.6)	NA	0.99	0.93	0.36 vs. 0.15	0.21 vs. 0.081
rs9267992	7.6×10−6	2.7 (1.8 – 4.1)	0.4	0.23	9.6×10−6	3.0 (1.9 – 4.9)	0.38	0.075	6.0×10−6	4.7 (2.4 – 9.1)	0.0019	0.0072	0.37	0.31 vs. 0.14	0.24 vs. 0.063
rs3135388	1.4×10−5	2.6 (1.7 – 4.0)	0.097	NA	3.9×10−5	2.8 (1.8 – 4.6)	0.89	NA	0.00011	4.3 (2.1 – 8.9)	0.11	NA	0.51	0.30 vs. 0.14	0.18 vs. 0.05
rs2523822	8.1×10−6	2.3 (1.6 – 3.4)	1.7×10−5	7.3×10−6	8.3×10−6	2.7 (1.8 – 4.1)	4.5×10−5	2.6×10−5	0.0051	2.0 (1.2 – 3.2)	0.032	0.043	0.65	0.49 vs. 0.28	0.43 vs. 0.28

MAF=minor allele frequency