Table 1.
Association estimates for the ten most significant associations observed in PanScan pleiotropy scan
| SNP | Chrom. | Gene Region | MAF (MA) | PanScan I (1,763 cases, 1,802 controls)
|
PanScan II (1,094 cases, 1,165 controls)
|
PanScan I+II (2,857 cases, 2,967 controls)
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| OR | 95% CI | P | PBonferroni | OR | 95% CI | P | P | PBonf | Pperm | ||||
| rs7310409 | 12 | HNF1A | 0.40 (A) | 1.22 | 1.11–1.35 | 0.00003 | 0.03 | 1.16 | 1.02–1.30 | 0.02 | 2×10−6 | 0.002 | 0.0008 |
| rs3748816 | 1 | MMEL1 | 0.33 (C) | 1.20 | 1.09–1.33 | 0.0002 | 0.21 | 0.88 | 0.78–1.00 | 0.05 | 0.66 | 1.00 | 1.00 |
| rs735396 | 12 | HNF1A | 0.38 (G) | 1.19 | 1.08–1.31 | 0.0005 | 0.51 | 1.10 | 0.97–1.24 | 0.14 | 0.0003 | 0.33 | 0.07 |
| rs7202877 | 16 | Intergenic | 0.11 (G) | 1.28 | 1.11–1.48 | 0.0009 | 1.00 | 1.19 | 0.99–1.43 | 0.07 | 0.0003 | 0.32 | 0.19 |
| rs2650000 | 12 | HNF1A | 0.37 (T) | 1.17 | 1.06–1.28 | 0.002 | 1.00 | 1.15 | 1.02–1.30 | 0.03 | 0.0001 | 0.11 | 0.04 |
| rs2736990 | 4 | SNCA | 0.45 (C) | 0.86 | 0.79–0.95 | 0.002 | 1.00 | 0.99 | 0.88–1.11 | 0.86 | 0.01 | 1.00 | 1.00 |
| rs727957 | 21 | KCNE1 | 0.18 (T) | 1.20 | 1.07–0.36 | 0.003 | 1.00 | 1.10 | 0.94–1.28 | 0.23 | 0.001 | 1.00 | 0.95 |
| rs2126259 | 8 | PPP1R3B | 0.09 (A) | 0.79 | 0.67–0.92 | 0.003 | 1.00 | 0.92 | 0.75–1.14 | 0.46 | 0.005 | 1.00 | 0.98 |
| rs9989419 | 16 | CETP | 0.40 (A) | 0.87 | 0.79–0.96 | 0.004 | 1.00 | 1.00 | 0.89–1.13 | 0.99 | 0.03 | 1.00 | 1.00 |
| rs9368699 | 6 | SNORD52 | 0.04 (C) | 0.69 | 0.53–0.88 | 0.004 | 1.00 | 1.10 | 0.82–1.48 | 0.53 | 0.07 | 1.00 | 1.00 |
MAF, minor allele frequency; MA, minor allele; OR, odds ratio; 95% CI, 95% confidence interval