Table 2.
A description of SNPs in the HNF1A region with associations reported in the NHGRI GWA study catalog
| SNP | r2 with rs7310409a | Associations reported in GWA catalog
|
PanScan I+II
|
||||||
|---|---|---|---|---|---|---|---|---|---|
| Associated Trait | Risk (or increaser) Allele | Reported P-value | Ref. | Best tagSNP (r2) | OR | CI | P | ||
| rs7310409 | N/A | C-reactive protein | A | 7 × 10−17 | (22, 31) | SNP present | 1.19 | 1.11–1.19 | 2×10−6 |
| rs1169310 | 0.71 | C-reactive protein | A | 2×10−8 | (21) | rs735396 (1.00) | 1.15 | 1.07–1.24 | 0.0003 |
| rs1183910 | 0.64 | C-reactive protein | T | 1×10−30 | (20) | rs2650000 (0.88) | 0.16 | 1.07–1.25 | 0.0001 |
| rs1169313 | 0.64 | Gamma-glutamyl transferase | C | 2×10−10 | (23) | rs735396 (1.00) | 1.15 | 1.07–1.24 | 0.0003 |
| rs2650000 | 0.45 | LDL cholesterol | A | 2×10−8 | (24) | SNP present | 0.16 | 1.07–1.25 | 0.0001 |
| rs7957197 | 0.11 | Type 2 diabetes | T | 2×10−8 | (26) | rs7965349 (0.82) | 0.97 | 0.88–1.07 | 0.52 |
| rs2259816 | 0.64 | Coronary heart disease | T | 5×10−7 | (25) | rs735396 (1.00) | 1.15 | 1.07–1.24 | 0.0003 |
| rs7953249 | 0.79 | N-glycan levels | G | 2×10−8 | (27) | rs7310409 (0.89) | 1.19 | 1.11–1.19 | 2×10−6 |
| rs735396 | 0.64 | N-glycan levels | G | 4×10−8 | (27) | SNP present | 1.15 | 1.07–1.24 | 0.0003 |
a
All r values are derived from HapMap3 CEU data