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. Author manuscript; available in PMC: 2012 Jul 1.
Published in final edited form as: J Neurochem. 2011 Jun 6;118(2):237–247. doi: 10.1111/j.1471-4159.2011.07308.x

Figure 5.

Figure 5

Viral mediated expression of GluR1(S845A) in the NAcc blocks AMPH-induced phosphorylation of GluR1 and AMPH-induced locomotion. (A) Representative immunoblots of GluR1(S845), GluR1, and Cop GFP, (B) pGluR1(S845) (***, P<0.001, vs remaining groups; Scheffé), and (C) GluR1 protein levels in rats not infected (Control), infected with Lenti-GFP, or infected with Lenti-GluR1(S845A) either challenged or not challenged with NAcc AMPH. n/group=5-6. (D) Photomicrographs of the NAcc obtained 3 weeks following infection with Lenti-GFP or Lenti-GluR1(S845A) illustrating GFP positive neurons in close proximity to the injection cannula tips (arrows). Scale bar = 50μm. (E) Locomotor activity counts obtained before and after (arrow) NAcc AMPH in the two groups (*, P<0.05, ***, P<0.001, vs Lenti-GFP; Scheffé). n/group=5-6. Data are shown as mean±SEM.