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Protective effects of endothelial nitric oxide synthase-derived nitric oxide. The multifactorial consequences are derived from the nitric oxide (NO) generation on oxidative stress (reactive oxygen species), proinflammatory [interleukins (ILs), tumor necrosis factor (TNF)] and vasoconstrictor (endothelins) mediators. e-NOS: Endothelial nitric oxide synthase; ROS: Reactive oxygen species.
