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. 2011 Apr 5;19(7):1230–1235. doi: 10.1038/mt.2011.58

Figure 2.

Figure 2

Efficient dystrophin transduction to dko mouse's diaphragm. (a) The structure of HDAdv-myc-mFLdys. CAGP, the CAG promoter; stuffer, a part of the murine Emx2 gene; full-length dystrophin, the murine full-length dystrophin complementary DNA (cDNA); ITR, inverted terminal repeat of adenovirus; PA, simian virus 40 polyadenylation signal; RSV, Raus sarcoma virus promoter; φ, packaging signal. Myc-tag was inserted into the dystrophin cDNA between 6,886 and 6,887 nucleotides. (b) Mosaic image of an entire diaphragm showing widespread full-length dystrophin. The bilateral sections from the diaphragms of injected 9-week-old dko mice were immunostained for dystrophin (dystrophinH-300; 1:100). Wide spread full-length dystrophin in the diaphragm. Bar = 100 µm.