Figure 5.

Improvement of respiratory function by dystrophin transduction. (a) The respiratory function of dko and age-matched wild-type mice were monitored by whole-body plethysmography, in which the animal was free to move around within an enclosed space. (b) Improvement of respiratory function in the 9-week-old injected dko mice. Uninjected 9-week-old dko mouse showed significantly decreased tidal volume (TV) and tachypnea compared with the age-matched (WT) wild-type mice. The injected dko mice showed increased TV and improvement of tachypnea (n = 6–7 mice/group, *P < 0.01, **P < 0.0001). TV was normalized by dividing by body weight (BW).