Figure 5.

Ad5/6 demonstrates reduced toxicity in vivo. (a) BALB/c mice were injected intravenous with up to 1 × 10¹¹ virus particles (vp) of adenovirus (Ad) vectors. Serum was harvested 30 minutes later and analyzed for lactate dehydrogenase levels. N = 3. BALB/c mice were injected intravenously with 2.5 × 10¹¹ vp of Ad vectors. (b) Serum was harvested at 72 hours and assayed for alanine aminotransferase (ALT) levels. N = 3. (c) Serum was harvested at 6 hours and assayed for interleukin-6 levels (IL-6). N = 3. **P < 0.005; ns = not significant. Means ± SEM.