Figure 7.

In vivo expression of unmodified and chimeric helper dependent vectors. BALB/c mice were injected with 1 × 10¹⁰ virus particles (vp) of either HD-Ad5GL or HD-Ad5/6GL by different routes. Mice were imaged 24 hours later using a Lumazone imager for 3 minutes at 1 × 1 binning, 1,320–1,600 gray values. Shown are (a) white light images overlaid with luciferase expression in pseudo-color. (b) Quantification of luciferase expression. Intramuscular, left and intravascular, right. N = 5. **P < 0.005; ns = not significant. Means ± SEM.