Table 4.
Hazard ratios for hip fracture in multivariate models including estimated cortical thickness and total femoral neck aBMD adjusted for height, weight and age (standardized for 1 SD decrease in all parameters).
| Women | |||||
|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | Model 4 | Model 5 | |
| HR 95% CI, p | HR 95% CI, p | HR 95% CI, p | HR 95% CI, p | HR 95% CI, p | |
| Any hip fracture | |||||
|
| |||||
| Avg CTh* (mm) | 1.2 (0.8-2.0), 0.35 | - | - | - | - |
| SP Est CTh (mm) | - | 1.2 (0.8-1.7), 0.35 | - | - | - |
| SA Est CTh (mm) | - | - | 1.5 (1.0-2.2), 0.04 | - | - |
| IP Est CTh (mm) | - | - | - | 0.7 (0.5-1.1), 0.11 | - |
| IA Est CTh (mm) | - | - | - | - | 1.2 (0.8-1.7), 0.35 |
| Femoral neck aBMD (gm/cm2) | 1.5 (0.9-2.5), 0.10 | 1.6 (1.1-2.4), 0.01 | 1.4 (0.9-2.0), 0.13 | 2.4 (1.5-3.7), 0.0001 | 1.6 (1.1-2.4), 0.01 |
|
| |||||
| Femoral Neck Fracture | |||||
|
| |||||
| Avg CTh* (mm) | 1.2 (0.6-2.2), 0.65 | - | - | - | - |
| SP Est CTh (mm) | - | 1.1 (0.7-1.8), 0.59 | - | - | - |
| SA Est CTh (mm) | - | - | 1.6 (1.0-2.8), 0.05 | - | - |
| IP Est CTh (mm) | - | - | - | 0.6 (0.3-1.1), 0.07 | - |
| IA Est CTh (mm) | - | - | - | - | 1.1 (0.7-1.8), 0.61 |
| Femoral neck aBMD (gm/cm2) | 1.5 (0.8-3.0), 0.22 | 1.6 (0.9-2.6), 0.09 | 1.2 (0.7-2.0), 0.52 | 2.6 (1.4-5.0), 0.002 | 1.6 (0.9-2.6), 0.08 |
|
| |||||
| Trochanteric Fracture | |||||
|
| |||||
| Avg CTh* (mm) | 1.4 (0.7-2.8), 0.33 | - | - | - | - |
| SP Est CTh (mm) | - | 1.3 (0.7-2.2), 0.37 | - | - | - |
| SA Est CTh (mm) | - | - | 1.6 (0.9-2.8), 0.13 | - | - |
| IP Est CTh (mm) | - | - | - | 0.8 (0.4-1.4), 0.45 | - |
| IA Est CTh (mm) | - | - | - | - | 1.3 (0.8-2.1), 0.37 |
| Femoral neck aBMD (gm/cm2) | 1.6 (0.8-3.2), 0.19 | 1.7 (1.0-3.1), 0.05 | 1.5 (0.8-2.7), 0.17 | 2.5 (1.3-4.8), 0.006 | 1.8 (1.0-3.1), 0.04 |
|
| |||||
| Men | |||||
|
| |||||
| Model 1 | Model 2 | Model 3 | Model 4 | Model 5 | |
|
|
|||||
| HR 95% CI, p | HR 95% CI, p | HR 95% CI, p | HR 95% CI, p | HR 95% CI, p | |
|
| |||||
| Any hip fracture | |||||
|
| |||||
| Avg CTh* (mm) | 2.2 (1.4-3.7), 0.001 | - | - | - | - |
| SP Est CTh (mm) | - | 1.2 (0.7-1.8), 0.50 | - | - | - |
| SA Est CTh (mm) | - | - | 2.8 (1.8-4.4), <0.0001 | - | - |
| IP Est CTh (mm) | - | - | - | 1.7 (1.1-2.5), 0.01 | - |
| IA Est CTh (mm) | - | - | - | - | 1.1 (0.7-1.7), 0.55 |
| Femoral neck aBMD (gm/cm2) | 1.6 (0.9-2.6), 0.09 | 2.8 (1.7-4.6), <0.0001 | 1.7 (1.1-2.5), 0.012 | 2.2 (1.4-3.4), 0.006 | 2.8 (1.6-4.7), 0.0001 |
|
| |||||
| Femoral Neck Fracture | |||||
|
| |||||
| Avg CTh* (mm) | 2.9 (1.5-5.5), 0.001 | - | - | - | - |
| SP Est CTh (mm) | - | 2.0 (1.1-3.6), 0.02 | - | - | - |
| SA Est CTh (mm) | - | - | 3.2 (1.8-5.7), <0.0001 | - | - |
| IP Est CTh (mm) | - | - | - | 1.4 (0.8-2.5), 0.20 | - |
| IA Est CTh (mm) | - | - | - | - | 1.4 (0.8-2.4), 0.24 |
| Femoral neck aBMD (gm/cm2) | 1.2 (0.7-2.2), 0.51 | 1.8 (1.0-3.2), 0.05 | 1.4 (0.8-2.4), 0.17 | 2.2 (1.2-4.0), 0.008 | 2.1 (1.1-4.1), 0.02 |
|
| |||||
| Trochanteric Fracture | |||||
|
| |||||
| Avg CTh* (mm) | 1.9 (0.8-4.4), 0.14 | - | - | - | - |
| SP Est CTh (mm) | - | 0.5 (0.2-1.1), 0.06 | - | - | - |
| SA Est CTh (mm) | - | - | 2.8 (1.3-5.9), 0.007 | - | - |
| IP Est CTh (mm) | - | - | - | 2.7 (1.4-5.0), 0.002 | - |
| IA Est CTh (mm) | - | - | - | - | 0.9 (0.4-1.9), 0.78 |
| Femoral neck aBMD (gm/cm2) | 2.7 (1.0-6.9), 0.04 | 8.7 (3.2-22.9), <0.0001 | 2.4 (1.2-4.9), 0.01 | 2.4 (1.2-5.0), 0.01 | 5.2 (2.1-13), 0.003 |
*
AvgCTh: average of the four quadrants.