Table 2.
Therapeutic responses of patients in the study*
| Characteristic | Group 1 (n = 68) | Group 2 (n = 69) | Group 3 (n = 66) | Group 4 (n = 64) | Group 5 (n = 66) | Group 6 (n = 66) |
|---|---|---|---|---|---|---|
| No. of dropouts | 8 | 12 | 10 | 16 | 14 | 17 |
| No. of patients who completed follow-up | 60 | 57 | 56 | 48 | 52 | 49 |
| Cure rate at day 28 (%) | 51 (85) | 51 (89) | 54 (94) | 48 (100) | 52 (100) | 47 (96) |
| Relapse rate at day 28 (%) | 9 (15) | 6 (11) | 2 (4) | 0 | 0 | 2 (4) |
| Day of appearance | 19, 20, 22, 23, 25, 28 | 20, 21, 23, 24, 28 | 14, 21 | NA | NA | 22, 23 |
| Mean (SD) fever clearance time, hr | 16.8 (14.4) | 20.0 (21.6) | 14.5 (9.3) | 13.8 (11.4) | 19.6 (22.2) | 21.4 (23.5) |
| Mean (SD) parasite clearance time, hr | 34.9 (8.4) | 36.0 (10.5) | 35.7 (10.1) | 34.2 (9.9) | 37.2 (11.4) | 36.8 (10.4) |
*
NA = not available. Group 1 ≠ group 4 and group 5 (P = 0.004 and 0.003). Group 2 ≠ group 4 and group 5 (P = 0.015 and 0.014).