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. Author manuscript; available in PMC: 2012 May 27.
Published in final edited form as: Immunity. 2011 May 19;34(5):755–768. doi: 10.1016/j.immuni.2011.02.020

Figure 7. FMF-associated B30.2 mutations activate an ASC-dependent but NALP3 independent pyrin inflammasome.

Figure 7

(A–C) Analyses of the FMF KI (MefvV726A/V726A) mice with Asc−/− background. (A) Flow cytometry analyses of peripheral blood cells from 8-week-old mice analyzed as in Figure 3C. Data are representative of three independent experiments. (B) Body weights of 8-week-old males. (C) Inflammasome activation in MefvV726A/V726A mice with Asc−/− background. Culture supernatants and lysates from BM CD11b+ cells were analyzed by immunoblotting. (D–E) Analyses of the FMF KI (MefvV726A/V726A) mice with Nlrp3−/− background. . (D) Inflammasome activation in MefvV726A/V726A mice with Nlrp3−/− background. Culture supernatants and lysates from BM CD11b+ cells were analyzed by immunoblotting. (E) Flow cytometry analyses of peripheral blood cells from 8-week-old mice analyzed as in Figure 3C. Data are representative of three independent experiments Additional information is provided in Figure S6.