Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2010 Oct;14(5):525–540. doi: 10.1089/omi.2010.0072

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright 2010, Mary Ann Liebert, Inc.

PMC Copyright notice

FIG. 1. — Mechanistic model for the adaptive yeast response to weak acid-induced stress. (A) Stimulation of the activity of H⁺-ATPases present in the plasma and vacuolar membranes contribute to the recovery of internal pH (pH_i) to more physiological values and for metabolite compartmentalization in acid-stressed cells. The reconfiguration of cell wall structure and plasma membrane lipid composition may reduce the diffusion rate of undissociated weak acids and reduce the weak acid-induced plasma membrane damage. (B) Detoxification through multidrug resistance (MDR) transporters of the ATP-binding cassette (ABC) (in yellow) and Major Facilitator Superfamily (MFS) (in pink) is required to reduce the internal concentration of the weak acid counterion. The substrates established for each MDR transporter are indicated based on the information available in the literature. 1) Tenreiro et al., 2000; 2) Tenreiro et al., 2002; 3) Fernandes et al., 2003; 4) Teixeira and Sá-Correia, 2002; 5) Ro et al., 2008; 6) Alenquer et al., 2006; 7) Desmoucelles et al., 2002; 8) Piper et al., 1998; 9) Hazelwood et al., 2006.

FIG. 1. — Mechanistic model for the adaptive yeast response to weak acid-induced stress. (A) Stimulation of the activity of H⁺-ATPases present in the plasma and vacuolar membranes contribute to the recovery of internal pH (pH_i) to more physiological values and for metabolite compartmentalization in acid-stressed cells. The reconfiguration of cell wall structure and plasma membrane lipid composition may reduce the diffusion rate of undissociated weak acids and reduce the weak acid-induced plasma membrane damage. (B) Detoxification through multidrug resistance (MDR) transporters of the ATP-binding cassette (ABC) (in yellow) and Major Facilitator Superfamily (MFS) (in pink) is required to reduce the internal concentration of the weak acid counterion. The substrates established for each MDR transporter are indicated based on the information available in the literature. 1) Tenreiro et al., 2000; 2) Tenreiro et al., 2002; 3) Fernandes et al., 2003; 4) Teixeira and Sá-Correia, 2002; 5) Ro et al., 2008; 6) Alenquer et al., 2006; 7) Desmoucelles et al., 2002; 8) Piper et al., 1998; 9) Hazelwood et al., 2006.